‼️‼️2021/5/25【日常速卡】第4批‼️‼️
⚠️主页拉黑教程https://t.cn/A6VtuWVp
最近投稿较多，辛苦大家打卡反黑，没有时间的话用魔饭生和分子一键反黑
【伪粉-主页拉黑】
1. https://t.cn/RmBuQ87
（id:宇野大专喜欢吹假B;uid:6020398480）
2. https://t.cn/EvfuQWV
（id:Eleanordamsel_;uid:3625474471）
【挂黑-主页拉黑】
1. https://t.cn/A6VbdT2m
（id：久菜合子xxxd；uid：7599130436）
2. https://t.cn/A6V473kX
（id:丽羊羊的耳环让你洄家备用号;uid:6426114696）
3. https://t.cn/A6cpLO59
（id:灿若银烂;uid:7574606702）
4. https://t.cn/A6VGAW9A
（id:洄洄真爱;uid:7503690103）
5. https://t.cn/A6c0rwcM
（id:平平无奇的洄妈罢了;uid:7596173794）
6. https://t.cn/AiYqMip8
（id:去芒果核的方师傅;uid:5680677023）
7. https://t.cn/A6cp1d5h
（id:赞哆才是唯一的世界冠军;uid:7507470079）
8. https://t.cn/A6VJyF6A
（id:看我主页别乱给我扣脏东西;uid:7546108983）
9. https://t.cn/A6cnUqGu
（id:义an885;uid:6900698476）
10. https://t.cn/A6tEhi2j
（id:趁你发病要你狗命;uid:6296491701）
11. https://t.cn/A6cSeNH9
（id:力汍迟早玩汍;uid:7577600693）
12. https://t.cn/A6cNVmeN
（id：华妃赐你洄宫；uid：1892350591）
13. https://t.cn/A6cy2GJg
（id：阿理椰奶_；uid：5667992310）
14. https://t.cn/A6cG0kUl
（id:猕猴桃滞销被猴子吃光;uid:7582328091）
【挂黑主页举报-yhxx-其他】
1. https://t.cn/A6VJI2oH
2. https://t.cn/A6VJI2o8
3. https://t.cn/A6VJI2oQ
4. https://t.cn/A6VJI2oT
5. https://t.cn/A6VJI2oR
6. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=5680677023&type=3&luicode=10000001
7. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7507470079&type=3&luicode=10000001
8. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7546108983&type=3&luicode=10000001
9. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=6900698476&type=3&luicode=10000001
10. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=6296491701&type=3&luicode=10000001
11. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7577600693&type=3&luicode=10000001
12. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=1892350591&type=3&luicode=10000001
13. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=5667992310&type=3&luicode=10000001
14. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7582328091&type=3&luicode=10000001
——————单条链接——————
【yhxx-其它】
1. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4290&rid=4639047169867845&type=1&luicode=10000001
2. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4290&rid=4637267257985885&type=1&luicode=10000001
3. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4290&rid=4640154163609913&type=1&luicode=10000001
4. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640866372944809&type=2&luicode=10000001
5. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640867849344353&type=2&luicode=10000001
6. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640867632286207&type=2&luicode=10000001
7. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640869976377359&type=2&luicode=10000001
8. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640873545469580&type=2&luicode=10000001
9. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640866377404905&type=2&luicode=10000001
10. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640868616901002&type=2&luicode=10000001
11. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640868101262042&type=2&luicode=10000001
12. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640876813620549&type=2&luicode=10000001
13. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640875668048890&type=2&luicode=10000001
14. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640875239969114&type=2&luicode=10000001
15. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640875499751070&type=2&luicode=10000001
16. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640872655751222&type=2&luicode=10000001
17. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640871599836740&type=2&luicode=10000001
18. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640871062444774&type=2&luicode=10000001
19. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640864703613791&type=2&luicode=10000001
20. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4639057458497431&type=1&luicode=10000001
⚠️完成后评论统一格式打卡：
倘若我是一束微光，倾尽全力为你绽放所有光芒 #力丸INTO1天才全能主舞#
查看投诉结果：https://t.cn/A6tCt2OC
⚠️主页拉黑教程https://t.cn/A6VtuWVp
最近投稿较多，辛苦大家打卡反黑，没有时间的话用魔饭生和分子一键反黑
【伪粉-主页拉黑】
1. https://t.cn/RmBuQ87
（id:宇野大专喜欢吹假B;uid:6020398480）
2. https://t.cn/EvfuQWV
（id:Eleanordamsel_;uid:3625474471）
【挂黑-主页拉黑】
1. https://t.cn/A6VbdT2m
（id：久菜合子xxxd；uid：7599130436）
2. https://t.cn/A6V473kX
（id:丽羊羊的耳环让你洄家备用号;uid:6426114696）
3. https://t.cn/A6cpLO59
（id:灿若银烂;uid:7574606702）
4. https://t.cn/A6VGAW9A
（id:洄洄真爱;uid:7503690103）
5. https://t.cn/A6c0rwcM
（id:平平无奇的洄妈罢了;uid:7596173794）
6. https://t.cn/AiYqMip8
（id:去芒果核的方师傅;uid:5680677023）
7. https://t.cn/A6cp1d5h
（id:赞哆才是唯一的世界冠军;uid:7507470079）
8. https://t.cn/A6VJyF6A
（id:看我主页别乱给我扣脏东西;uid:7546108983）
9. https://t.cn/A6cnUqGu
（id:义an885;uid:6900698476）
10. https://t.cn/A6tEhi2j
（id:趁你发病要你狗命;uid:6296491701）
11. https://t.cn/A6cSeNH9
（id:力汍迟早玩汍;uid:7577600693）
12. https://t.cn/A6cNVmeN
（id：华妃赐你洄宫；uid：1892350591）
13. https://t.cn/A6cy2GJg
（id：阿理椰奶_；uid：5667992310）
14. https://t.cn/A6cG0kUl
（id:猕猴桃滞销被猴子吃光;uid:7582328091）
【挂黑主页举报-yhxx-其他】
1. https://t.cn/A6VJI2oH
2. https://t.cn/A6VJI2o8
3. https://t.cn/A6VJI2oQ
4. https://t.cn/A6VJI2oT
5. https://t.cn/A6VJI2oR
6. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=5680677023&type=3&luicode=10000001
7. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7507470079&type=3&luicode=10000001
8. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7546108983&type=3&luicode=10000001
9. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=6900698476&type=3&luicode=10000001
10. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=6296491701&type=3&luicode=10000001
11. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7577600693&type=3&luicode=10000001
12. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=1892350591&type=3&luicode=10000001
13. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=5667992310&type=3&luicode=10000001
14. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=7582328091&type=3&luicode=10000001
——————单条链接——————
【yhxx-其它】
1. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4290&rid=4639047169867845&type=1&luicode=10000001
2. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4290&rid=4637267257985885&type=1&luicode=10000001
3. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4290&rid=4640154163609913&type=1&luicode=10000001
4. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640866372944809&type=2&luicode=10000001
5. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640867849344353&type=2&luicode=10000001
6. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640867632286207&type=2&luicode=10000001
7. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640869976377359&type=2&luicode=10000001
8. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640873545469580&type=2&luicode=10000001
9. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640866377404905&type=2&luicode=10000001
10. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640868616901002&type=2&luicode=10000001
11. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640868101262042&type=2&luicode=10000001
12. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640876813620549&type=2&luicode=10000001
13. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640875668048890&type=2&luicode=10000001
14. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640875239969114&type=2&luicode=10000001
15. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640875499751070&type=2&luicode=10000001
16. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640872655751222&type=2&luicode=10000001
17. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640871599836740&type=2&luicode=10000001
18. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640871062444774&type=2&luicode=10000001
19. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4640864703613791&type=2&luicode=10000001
20. https://service.account.weibo.com/reportspamobile?ua=Mozilla%2F5.0+%28iPhone%3B+CPU+iPhone+OS+14_4+like+Mac+OS+X%29+AppleWebKit%2F605.1.15+%28KHTML%2C+like+Gecko%29+Mobile%2F15E148+WeiboIntliOS_iPhone_4300&rid=4639057458497431&type=1&luicode=10000001
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#金斯瑞生物# #生物资讯小“G”者# #南京·金斯瑞生物科技公司[地点]#
[话筒]百时美施贵宝Relatlimab&Nivolumab2/3期临床结果积极
日前，据外媒报道，BMS在5月19日宣布了2/3 RELATIVITY-047研究的结果，研究结果表明LAG-3阻断抗体Relatlimab和Nivolumab的固定剂量组合作为单次输液，在既往未治疗的转移性或不可切除的黑色素瘤患者中，与单用Nivolumab相比，显示了具有统计学意义和临床意义的无进展生存期(PFS)获益。RELATIVITY-047研究采用随机、双盲设计，评估固定剂量Relatlimab 160mg和Nivolumab 480mg组合相比Nivolumab的疗效和安全性差异。试验共纳入714例患者，按1:1分组，分别为Relatlimab（160 mg）+Nivolumab组（480 mg）和Nivolumab组（480 mg），每4周给药1次，在接受联合治疗的患者中，中位无生存期(mPFS)在10.12个月(95%置信区间[CI]: 6.37-15.74)显著长于接受单抗治疗的患者的4.63个月(95% CI: 3.38-5.62);(危险比[HR] 0.75;95% CI: 0.62-0.92, p=0.0055)。固定剂量联合用药的PFS益处在第一次扫描时就很早观察到了，并且随时间推移是一致的。在探索性、描述性分析中，无论预先设定的亚组和分层因素如何，Relatlimab和Nivolumab的组合均可延长PFS。
[话筒]阿诺医药向FDA递交新药AN4005临床申请
5月20日，阿诺医药宣布已向美国FDA递交了其原创新药口服PD-L1抑制剂AN4005的临床试验申请（IND）。阿诺医药将开展此药物安全性和药代动力学评估的临床1期试验，患者入组也将于美国启动。AN4005可有效诱导和稳定PD-L1二聚体的形成及二聚化，从而有力地破坏PD-1/PD-L1蛋白质间的相互作用。临床前研究表明，AN4005具备出色的体外活性和体内抗肿瘤功效，以及良好的成药性和安全性。更重要的是，AN4005表现出相当的体外和体内活性，与其他免疫检查点抑制剂一样都严格依赖于免疫系统。
[话筒]FDA批准的首款EZH2抑制剂在华申报临床
5月19日，CDE官网显示Epizyme公司Tazemetostat（他折司他）临床申请已获国家药监局受理，是国内第3家申报临床的EZH2抑制剂。Tazemetostat是一款first in class组蛋白赖氨酸甲基转移酶（EZH2）抑制剂，可通过抑制PRC2中EZH2酶的活性恢复抑癌基因的表达，达到肿瘤抑制作用。Tazemetostat最早于2020年1月24日获FDA批准上市，用于用于治疗不适合完全切除的转移性/局部晚期上皮样肉瘤（ES）成人和16岁及以上儿科患者。2020年6月Tazemetostat第2项适应证获得FDA批准，用于治疗既往经过至少二线系统治疗EZH2+复发或难治性（r/r）滤泡性淋巴瘤（FL）成人患者或无其他替代疗法的r/r FL成人患者。Tazemetostat是首个获FDA批准的EZH2抑制剂。
[话筒]百时美施贵宝Relatlimab&Nivolumab2/3期临床结果积极
日前，据外媒报道，BMS在5月19日宣布了2/3 RELATIVITY-047研究的结果，研究结果表明LAG-3阻断抗体Relatlimab和Nivolumab的固定剂量组合作为单次输液，在既往未治疗的转移性或不可切除的黑色素瘤患者中，与单用Nivolumab相比，显示了具有统计学意义和临床意义的无进展生存期(PFS)获益。RELATIVITY-047研究采用随机、双盲设计，评估固定剂量Relatlimab 160mg和Nivolumab 480mg组合相比Nivolumab的疗效和安全性差异。试验共纳入714例患者，按1:1分组，分别为Relatlimab（160 mg）+Nivolumab组（480 mg）和Nivolumab组（480 mg），每4周给药1次，在接受联合治疗的患者中，中位无生存期(mPFS)在10.12个月(95%置信区间[CI]: 6.37-15.74)显著长于接受单抗治疗的患者的4.63个月(95% CI: 3.38-5.62);(危险比[HR] 0.75;95% CI: 0.62-0.92, p=0.0055)。固定剂量联合用药的PFS益处在第一次扫描时就很早观察到了，并且随时间推移是一致的。在探索性、描述性分析中，无论预先设定的亚组和分层因素如何，Relatlimab和Nivolumab的组合均可延长PFS。
[话筒]阿诺医药向FDA递交新药AN4005临床申请
5月20日，阿诺医药宣布已向美国FDA递交了其原创新药口服PD-L1抑制剂AN4005的临床试验申请（IND）。阿诺医药将开展此药物安全性和药代动力学评估的临床1期试验，患者入组也将于美国启动。AN4005可有效诱导和稳定PD-L1二聚体的形成及二聚化，从而有力地破坏PD-1/PD-L1蛋白质间的相互作用。临床前研究表明，AN4005具备出色的体外活性和体内抗肿瘤功效，以及良好的成药性和安全性。更重要的是，AN4005表现出相当的体外和体内活性，与其他免疫检查点抑制剂一样都严格依赖于免疫系统。
[话筒]FDA批准的首款EZH2抑制剂在华申报临床
5月19日，CDE官网显示Epizyme公司Tazemetostat（他折司他）临床申请已获国家药监局受理，是国内第3家申报临床的EZH2抑制剂。Tazemetostat是一款first in class组蛋白赖氨酸甲基转移酶（EZH2）抑制剂，可通过抑制PRC2中EZH2酶的活性恢复抑癌基因的表达，达到肿瘤抑制作用。Tazemetostat最早于2020年1月24日获FDA批准上市，用于用于治疗不适合完全切除的转移性/局部晚期上皮样肉瘤（ES）成人和16岁及以上儿科患者。2020年6月Tazemetostat第2项适应证获得FDA批准，用于治疗既往经过至少二线系统治疗EZH2+复发或难治性（r/r）滤泡性淋巴瘤（FL）成人患者或无其他替代疗法的r/r FL成人患者。Tazemetostat是首个获FDA批准的EZH2抑制剂。
#彤少雅思公厂# 【#贝壳创始人左晖去世# 】Zuo Hui, Founder and Chairman of Shell(Beike), passed away on May 20, 2021 due to an unexpected deterioration of his illness. To quote what he once said"The fate of business operators in our era is to do the hard work behind the fireworks and to really improve the quality of basic services.”, we express our deepest condolences to him and his family. Thank you Mr. Zuo for making intermediary service agencies a dignified industry. May he rest in peace.[蜡烛][蜡烛][蜡烛]
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