【#丝路上的新征程# 幕后花絮】达卡的农村,有种美而不自知的绝世恬静。CGTN摄制组走访了达舍尔甘地污水处理厂以及附近的村庄,这里最多的时候有三百号人在厂里工作。他们是污水处理厂建设的直接受益者,也是流经村落的各条河流水质显著提升的见证者。 #丝路惊鸿#
In the rural areas of Dhaka, there is a kind of beauty unknown to many. This village is located near the Dasherkandi Sewage Treatment Plant. As many as 300 people from the village earned a living at the plant during the height of its construction. They are the direct beneficiaries of the construction of the plant as well as witnesses to the significant improvement of the water quality of the rivers flowing through the village.
In the rural areas of Dhaka, there is a kind of beauty unknown to many. This village is located near the Dasherkandi Sewage Treatment Plant. As many as 300 people from the village earned a living at the plant during the height of its construction. They are the direct beneficiaries of the construction of the plant as well as witnesses to the significant improvement of the water quality of the rivers flowing through the village.
Hepatology International | 晚期慢性肝病患者的血管性血友病的因子加工及其与门静脉高压和临床结局的关系
在晚期慢性肝病(ACLD)中,血管性血友病因子抗原(VWF-Ag)水平的升高反映了内皮功能障碍和门静脉高压(PH)。本研究研究了VWF的释放和裂解,以及它们与PH值和临床结果的关系。
作者评估了229例临床稳定的ACLD患者中VWF-Ag、VWF-N(VWF-前肽)和VWF-A(由主要VWF切割蛋白酶ADAMTS 13加工的VWF)水平(肝静脉压力梯度[HVPG] ≥ 6 mmHg;不存在细菌感染或急性代偿失调)。肝脏健康个体作为对照(n = 24)。
VWF-Ag和VWF-N鉴别代偿期ACLD中有临床意义PH (CSPH;HVPG≥10 mmHg)的准确性相似(AUROC: VWF-Ag 0.748;VWF-N 0.728)。ADAMTS13活性在ACLD患者和对照组之间相似,并且与PH和疾病严重程度无关,而VWF裂解在CSPH患者中降低(即VWF-ag/a比值升高)。
体外VWF活性强烈反映了VWF- ag水平(Spearman's r = 0.874, p < 0.001),但当VWF-Ag水平标准化后,CSPH患者的VWF活性(VWF-activity/-Ag比值)降低(与对照组相比)。VWF-Act/-Ag比值与ADAMTS13活性呈负相关(r=-0.256,p<0.001)。ADAMTS13活性可独立预测:(i)门静脉血栓形成(PVT)和(ii)肝功能失代偿或肝脏相关死亡。
VWF-Ag水平及其前肽同样适用于代偿性ACLD患者的PH。ADAMTS13-Act与疾病和PH严重程度无关,当VWF-Ag标准化时,与肝脏健康个体相比,CSPH患者的VWF裂解和VWF活性均降低。低ADAMTS13-Act可能与更多的促凝血VWF和不良结局相关。
这项研究表明,与ADAMTS13切割的VWF-A相比,VWF-Ag水平及其前肽VWF-N是ACLD患者更好的PH生物标志物。在临床稳定条件下,ADAMTS13-Act与疾病严重程度和循环VWF-A无关。虽然VWF-Ag水平强烈反映了体外胶原结合能力,但在ADAMTS13-Act低的患者中,VWF-Act异常高,可能导致促凝状态。
摘译自 Simbrunner B, Villesen IF, Scheiner B, et al. Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome. Hepatol Int. 2023 Aug 21. doi: 10.1007/s12072-023-10577-y.
吉林大学第一医院肝胆胰内科 张玉 温晓玉 报道
在晚期慢性肝病(ACLD)中,血管性血友病因子抗原(VWF-Ag)水平的升高反映了内皮功能障碍和门静脉高压(PH)。本研究研究了VWF的释放和裂解,以及它们与PH值和临床结果的关系。
作者评估了229例临床稳定的ACLD患者中VWF-Ag、VWF-N(VWF-前肽)和VWF-A(由主要VWF切割蛋白酶ADAMTS 13加工的VWF)水平(肝静脉压力梯度[HVPG] ≥ 6 mmHg;不存在细菌感染或急性代偿失调)。肝脏健康个体作为对照(n = 24)。
VWF-Ag和VWF-N鉴别代偿期ACLD中有临床意义PH (CSPH;HVPG≥10 mmHg)的准确性相似(AUROC: VWF-Ag 0.748;VWF-N 0.728)。ADAMTS13活性在ACLD患者和对照组之间相似,并且与PH和疾病严重程度无关,而VWF裂解在CSPH患者中降低(即VWF-ag/a比值升高)。
体外VWF活性强烈反映了VWF- ag水平(Spearman's r = 0.874, p < 0.001),但当VWF-Ag水平标准化后,CSPH患者的VWF活性(VWF-activity/-Ag比值)降低(与对照组相比)。VWF-Act/-Ag比值与ADAMTS13活性呈负相关(r=-0.256,p<0.001)。ADAMTS13活性可独立预测:(i)门静脉血栓形成(PVT)和(ii)肝功能失代偿或肝脏相关死亡。
VWF-Ag水平及其前肽同样适用于代偿性ACLD患者的PH。ADAMTS13-Act与疾病和PH严重程度无关,当VWF-Ag标准化时,与肝脏健康个体相比,CSPH患者的VWF裂解和VWF活性均降低。低ADAMTS13-Act可能与更多的促凝血VWF和不良结局相关。
这项研究表明,与ADAMTS13切割的VWF-A相比,VWF-Ag水平及其前肽VWF-N是ACLD患者更好的PH生物标志物。在临床稳定条件下,ADAMTS13-Act与疾病严重程度和循环VWF-A无关。虽然VWF-Ag水平强烈反映了体外胶原结合能力,但在ADAMTS13-Act低的患者中,VWF-Act异常高,可能导致促凝状态。
摘译自 Simbrunner B, Villesen IF, Scheiner B, et al. Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome. Hepatol Int. 2023 Aug 21. doi: 10.1007/s12072-023-10577-y.
吉林大学第一医院肝胆胰内科 张玉 温晓玉 报道
【#丝路上的新征程# 幕后花絮】达卡的农村,有种美而不自知的绝世恬静。CGTN摄制组走访了达舍尔甘地污水处理厂以及附近的村庄,这里最多的时候有三百号人在厂里工作。他们是污水处理厂建设的直接受益者,也是流经村落的各条河流水质显著提升的见证者。 #丝路惊鸿# In the rural areas of Dhaka, there is a kind of beauty unknown to many. This village is located near the Dasherkandi Sewage Treatment Plant. As many as 300 people from the village earned a living at the plant during the height of its construction. They are the direct beneficiaries of the construction of the plant as well as witnesses of the the significant improvement of the water quality of the rivers flowing through the village. #TheNewSilkRoad#
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