l think the sign of a trus soulmate isn’t someone you just want to do the super cool stuff with. Ａ real soulmate is the person who makes any ordinary day fun. Some people make all these huge olans to do with their special someone .Fuck that.Find someone who you can take grocery shopping and still have ａblast with.Find someone who makes you look forward to waking up on Manday.
我认为真正的灵魂伴侣的标志不是你只想跟他一起做超酷的事情。真正的灵魂伴侣是能让任何平凡的日子变得有趣的人。找一个你可以去杂货店购物，还能一起玩得开心的人。找一个让你期待周一醒来的人

【什么时候需要行前列腺穿刺活检？】(1) 前列腺穿刺适应证：① 直肠指检发现前列腺可疑结节，任何PSA值；② TRUS或MRI发现可疑病灶，任何PSA值；③ PSA>10ng/ml，任何f/t PSA和PSAD值；④ PSA 4~10ng/ml，异常f/t PSA值和/或PSAD值。

注：PSA 4~10ng/ml，如f/t PSA、PSAD值、影像学正常，应严密随访。

(2) 重复穿刺：第一次前列腺穿刺结果为阴性，但DRE、复查PSA或其他衍生物水平提示可疑前列腺癌时，可考虑再次行前列腺穿刺。重复穿刺指征为：① 第一次穿刺病理发现不典型小腺泡增生(ASAP)或高级别上皮内瘤变(HGPIN)，尤其是多针穿刺结果如上时；② 复查PSA>10ng/ml；③ 复查PSA 4~10ng/ml，f/t PSA或PSAD值异常或直肠指检或影像学异常；④ 复查PSA 4~10ng/ml，复查 f/t PSA、PSAD、直肠指检、影像学均正常，则严密随访，每3个月复查PSA。如PSA连续2次>10ng/ml或PSAV>0.75/ml/年，应重复穿刺。

重复穿刺的时机：2次穿刺间隔时间尚不确定，推荐3个月或更长时间。

重复穿刺前除常规检查外，建议mpMRI检查，并进行基于mpMRI的靶向穿刺，能够提高穿刺阳性率，尤其是具有临床意义前列腺癌的检出率。

(3) 前列腺穿刺活检禁忌证：① 处于急性感染期、发热期；② 有高血压危象；③ 处于心脏功能不全失代偿期；④ 有严重出血倾向的疾病；⑤ 高血压、糖尿病等合并症控制不良；⑥ 合并严重的内、外痔，肛周或直肠病变者不宜经直肠途径穿刺

Don't worry your words that you said,I put in my heart and mind and thank you for always reminding me that.To be happy, to stay positive and trus. You always ask what I really want and I also ask what should I do but still we have the same answer. I said I want to be happy and you said if I'm happy you are happy so let's happiness very in our ❤