在药物化学设计中，我们通常会面临单点、两点或三点接触的铰链模板的选择。 虽然很容易将更多铰链接触的骨架视为优选，但辉瑞公司的数据表明应以视情况而决定。完全满足所有三个铰链氢键的片段在结合亲和力或选择性上没有普遍优势。 简单的吡啶是最常见的骨架之一。 这种单点骨架的流行说明了它的实用性和价值，据此开发了许多用于肿瘤适应症的晚期激酶抑制剂。 Xing, L.; Klug-Mcleod, J.; Rai, B.; Lunney, E. A. Kinase Hinge Binding Scaffolds and Their Hydrogen Bond Patterns. Bioorganic Med. Chem. 2015, 23 (19), 6520–6527. https://t.cn/A6JXCqb9
#计算机辅助药物设计##药物化学#

菲律宾超级台风，圣诞来了，他们却成了无家可归的人。
More than a week after Super Typhoon Rai -- known locally as Odette -- slammed into the Philippines, Lacia has given up trying to salvage whatever is left of his home. Not a single house stands anymore in his village on nearby Dinagat Island.
"Everything was gone, including my house," Lacia said. "The roof, and any wood that we built with, was gone."
All of the family's food was destroyed by floods. Their stock of rice -- a staple for the Southeast Asian country -- was floating in muddy water next to broken pieces of wood. Sayson's children's clothes are ruined from the rain, and her furniture reduced to fragments.
Sayson's kitchen appliances were stolen in the aftermath. She cannot afford to rebuild from scratch, she said.
"We need money to rebuild our house," she said. "We are not dreaming of having a mansion. All we want is to have our own house to live in so that our children are safe."

泰国MUEANG CHIANG RAI高速公路加油站旁边的咖啡店Paragraph Cafe，由IS Architects设计完成。

A paragraph is made up of a lot of words. The term Cafe comes from the fact that it is housed inside a gas station on the main road between Chiang Rai and Thoeng districts, allowing users to have a unique architectural experience. To act in order to change this area and context into a new tourist attraction on the major tourist route of the country's most visited provinces. https://t.cn/RU1yaH1