#Drug Research# When mating with intact female rats, no changes in sexual behavior were observed, but the index of the ability to fertilize and conceive decreased when compared to the values of the control group by 35–40% (TD index=60%) and by 75–80% (10 TD index=20%). The index of the ability to fertilize and conceive differed from the values of the control group by 90% (TD index=5%) and by 15% (10 TD index=80%). There were no differences in the indicator of embryotoxicity and teratogenicity in intact and drug-treated female rats, compared with the control group. Lipophtalocyan has a negative effect on the male and female reproductive function in rats and has an embryotoxic effect according to the index of the ability to fertilize and conceive, as well as the indices of preimplantation and post-implantation fetal death. The drug does not have a teratogenic effect, neither it affects the physical development of offspring or the rate of maturation of sensory-motor reflexes during feeding.
免费阅读全文：Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan https://t.cn/A6xrI1U1
免费阅读全文：Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan https://t.cn/A6xrI1U1
The system wasn't built for you and me. It was built for the elite. for the rats willing to do whatever it takes to line their pockets. if they are the rats we are the cockroaches. we survive and fight on no matter how hard they try to stop us. it's time we bring chaos to the system set up to stop us. we are System Chaos.
这个体制不是为你我设计的。它是为高层建造的。因为老鼠愿意不惜一切代价来掏腰包。如果他们是老鼠，我们就是杀不死的蟑螂。不管他们怎么阻止我们，我们都能生存并继续战斗。现在是给这个阻止我们的体制制造暴乱的时候了 。我们是System Chaos！
这个体制不是为你我设计的。它是为高层建造的。因为老鼠愿意不惜一切代价来掏腰包。如果他们是老鼠，我们就是杀不死的蟑螂。不管他们怎么阻止我们，我们都能生存并继续战斗。现在是给这个阻止我们的体制制造暴乱的时候了 。我们是System Chaos！
【Effects of Dexamethasone, Clonidine, Tramadol and Nalbuphine on Fentanyl-Induced Hyperalgesia in Rats】
#论文# #疼痛# #痛觉过敏# #药物研究#
Studies have demonstrated that opioids are medicines that are fundamental to pain treatment, however, these drugs can also cause an increase in pain sensitivity, which is called opioid-induced hyperalgesia. This study describes the effects of the drugs: dexamethasone, clonidine, tramadol and nalbuphine on fentanyl-induced hyperalgesia in rats using a standard plantar surgical incision.
DOI: 10.4236/jbm.2021.912007 https://t.cn/A6xmUmNK
#论文# #疼痛# #痛觉过敏# #药物研究#
Studies have demonstrated that opioids are medicines that are fundamental to pain treatment, however, these drugs can also cause an increase in pain sensitivity, which is called opioid-induced hyperalgesia. This study describes the effects of the drugs: dexamethasone, clonidine, tramadol and nalbuphine on fentanyl-induced hyperalgesia in rats using a standard plantar surgical incision.
DOI: 10.4236/jbm.2021.912007 https://t.cn/A6xmUmNK
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