SUMMARY
Background：The findings of epidemiologic studies on the association between egg consumption and ovarian cancer risk remain conflicting. The aim of this meta-analysis was to investigate whether an association exists between egg intake and ovarian cancer risk in epidemiologic studies.
Methods：A literature search was carried out using PUBMED, EMBASE, and Cochrane Library Central database for all medical literature published in English-language journals up to August 2013. Before meta- analysis, between-study heterogeneity and publication bias were assessed using adequate statistical tests. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analysis were also performed.
Results：A total of 12 eligible studies (six case-control studies and six cohort studies) were included, involving 629,453 subjects and 3728 ovarian cancer cases. We found that high egg intake (comparing the highest with the lowest category) was associated with a significant increased risk of ovarian cancer (RR ¼ 1.21, 95% CI [1.06, 1.38]). When we examined whether the associations differed by study type, statistically significant effect of egg intake on ovarian cancer was observed among case-control studies (RR ¼ 1.22, 95% CI [1.03, 1.43]), but not among cohort studies (RR ¼ 1.20, 95% CI [0.97, 1.48]).
Conclusions：Our findings suggest that egg consumption may increase ovarian cancer risk. Additional studies, especially large prospective cohort studies, are warranted to confirm the findings.
（塞尔维亚）《临床营养学》
【标题】鸡蛋消费与卵巢癌风险增加有关：证据来自一项观察性研究的荟萃分析
【作者】Sai-tian Zeng, Liang Guo*, Shi-kai Liu, Dong-hui Wang, Jie Xi, Ping Huang, Dan-tong Liu, Jie-fan Gao, Jing Feng, Liang Zhang
河北医科大学沧州中心医院妇科
【摘要】
1、背景：流行病学研究发现在关于鸡蛋摄入与卵巢癌风险之间的相关性上仍是矛盾的。本文这项荟萃分析的目的是调查流行病学研究中鸡蛋摄入量与卵巢癌风险之间是否存在关联。
2、方法：使用了PUBMED、EMBASE和Cochrane图书馆中央数据库，检索时间截止到2013年8月在英文期刊上发表的所有医学文献。在进行荟萃分析之前，使用了充分的统计检验来评估研究间的异质性和发表偏倚。使用了固定效应和随机效应模型评估总结相对风险(RR)和相应95%置信区间(CIs)。进行了亚组分析和敏感性分析。
3、结果：共纳入12项符合条件的研究(6项病例对照研究和6项队列研究)，涉及629453名受试者和3728例卵巢癌病例。我们发现，较高的鸡蛋摄入量(与最低类别相比)与卵巢癌风险显著增加相关(RR=1.21，95%CI[1.06，1.38])。当我们检查这些关联是否因研究类型不同而不同时，在病例对照研究中(RR=1.22，95%CI[1.03，1.43])观察到鸡蛋摄入对卵巢癌风险有统计学意义，但在队列研究中没有观察到(RR=1.20，95%CI[0.97，1.48])。
4、结论：我们的研究显示，摄入鸡蛋可能增加卵巢癌的风险。另外相关的研究，特别是大型的前瞻性队列研究，可确保证实这一发现。
#常观世音微语录[超话]##常观世音微语录#
Background：The findings of epidemiologic studies on the association between egg consumption and ovarian cancer risk remain conflicting. The aim of this meta-analysis was to investigate whether an association exists between egg intake and ovarian cancer risk in epidemiologic studies.
Methods：A literature search was carried out using PUBMED, EMBASE, and Cochrane Library Central database for all medical literature published in English-language journals up to August 2013. Before meta- analysis, between-study heterogeneity and publication bias were assessed using adequate statistical tests. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analysis were also performed.
Results：A total of 12 eligible studies (six case-control studies and six cohort studies) were included, involving 629,453 subjects and 3728 ovarian cancer cases. We found that high egg intake (comparing the highest with the lowest category) was associated with a significant increased risk of ovarian cancer (RR ¼ 1.21, 95% CI [1.06, 1.38]). When we examined whether the associations differed by study type, statistically significant effect of egg intake on ovarian cancer was observed among case-control studies (RR ¼ 1.22, 95% CI [1.03, 1.43]), but not among cohort studies (RR ¼ 1.20, 95% CI [0.97, 1.48]).
Conclusions：Our findings suggest that egg consumption may increase ovarian cancer risk. Additional studies, especially large prospective cohort studies, are warranted to confirm the findings.
（塞尔维亚）《临床营养学》
【标题】鸡蛋消费与卵巢癌风险增加有关：证据来自一项观察性研究的荟萃分析
【作者】Sai-tian Zeng, Liang Guo*, Shi-kai Liu, Dong-hui Wang, Jie Xi, Ping Huang, Dan-tong Liu, Jie-fan Gao, Jing Feng, Liang Zhang
河北医科大学沧州中心医院妇科
【摘要】
1、背景：流行病学研究发现在关于鸡蛋摄入与卵巢癌风险之间的相关性上仍是矛盾的。本文这项荟萃分析的目的是调查流行病学研究中鸡蛋摄入量与卵巢癌风险之间是否存在关联。
2、方法：使用了PUBMED、EMBASE和Cochrane图书馆中央数据库，检索时间截止到2013年8月在英文期刊上发表的所有医学文献。在进行荟萃分析之前，使用了充分的统计检验来评估研究间的异质性和发表偏倚。使用了固定效应和随机效应模型评估总结相对风险(RR)和相应95%置信区间(CIs)。进行了亚组分析和敏感性分析。
3、结果：共纳入12项符合条件的研究(6项病例对照研究和6项队列研究)，涉及629453名受试者和3728例卵巢癌病例。我们发现，较高的鸡蛋摄入量(与最低类别相比)与卵巢癌风险显著增加相关(RR=1.21，95%CI[1.06，1.38])。当我们检查这些关联是否因研究类型不同而不同时，在病例对照研究中(RR=1.22，95%CI[1.03，1.43])观察到鸡蛋摄入对卵巢癌风险有统计学意义，但在队列研究中没有观察到(RR=1.20，95%CI[0.97，1.48])。
4、结论：我们的研究显示，摄入鸡蛋可能增加卵巢癌的风险。另外相关的研究，特别是大型的前瞻性队列研究，可确保证实这一发现。
#常观世音微语录[超话]##常观世音微语录#
cum Pater in aere se Franciscus filiis, absens，novo genere signi，presentabat. （Responsoria IX，officium/sant'antonio）
Scomparto dipinto da #taddeodibartolo##eptittico# opistografo di #sanfrancescoalprato#，1403
Colletion dr. J.H. van Heek，Huis Bergh Castle
#assisi ##perugia##umbria
#sanfrancescodassisi##santantoniodipadova#
Scomparto dipinto da #taddeodibartolo##eptittico# opistografo di #sanfrancescoalprato#，1403
Colletion dr. J.H. van Heek，Huis Bergh Castle
#assisi ##perugia##umbria
#sanfrancescodassisi##santantoniodipadova#
Abstract
Evidence suggests that egg intake may be implicated in the aetiology of sex hormone-related cancers. However, dose–response relationships between egg intake and such cancers are unclear. Thus, we conducted a dose–response meta-analysis to summarise the dose–response relationships between egg consumption and the risk of breast, prostate and gynaecological cancers. A literature search was performed using PubMed and Embase up to April 2015 to identify relevant prospective observational studies. Summary relative risk (RR) and 95% CI were estimated using a random-effects model. For breast cancer, the linear dose–response meta-analysis found a non-significantly increased risk (RR for an increase of 5 eggs consumed/week: 1.05, 95% CI 0.99, 1.11, n 16023 cases). Evidence for non-linearity was not statistically significant (Pnon-linearity =0.50, n 15415 cases) but consuming ≥5 eggs/week was significantly associated with an increased risk of breast cancer compared with no egg consumption, with the summary RR being 1·04 (95% CI 1.01, 1.07) for consuming 5 eggs/week and 1·09 (95% CI 1.03, 1.15) for consuming about 9 eggs/week. For other cancers investigated, the summary RR for an increase of 5 eggs consumed/week was 1·09 (95% CI 0.96, 1.24, n 2636 cases) for ovarian cancer; 1.47 (95% CI 1.01, 2.14, n 609 cases) for fatal prostate cancer, with evidence of small-study effects (PEgger =0.04). No evidence was found for an association with the risk of total prostate cancer. While our conclusion was tempered by the potential for publication bias and confounding, high egg intake may be associated with a modestly elevated risk of breast cancer, and a positive association between egg intake and ovarian and fatal prostate cancers cannot be ruled out.
《英国营养学杂志》(2015)，114，1099-1107
标题：鸡蛋的摄入与乳腺癌、卵巢癌和前列腺癌：一项前瞻性观察研究的剂量反应荟萃分析
作者：N. keum【1，2】 *， D. H. Lee【1，2】, N. Marchand1, H. oh【1，2】, H. Liu【3】, D. aune【4，5】, D. C. Greenwood【6】，E. L. giovannucci1,【2，7】
1、美国波士顿哈佛大学陈曾熙公共卫生学院营养学系
2、美国波士顿哈佛大学陈曾熙公共卫生学院流行病学系
3、中国浙江大学流行病学与卫生统计学系
4、挪威特隆赫姆挪威科技大学医学院公共安全与综合医疗系
5、英国伦敦帝国理工学院流行病学与生物统计学系
6、英国利兹大学生物统计学系
7、美国马萨诸塞州波士顿布列根和妇女医院和哈佛医学院医学部钱宁网络医学系
摘要：
1、有证据表明，与性激素相关的癌症的病因可能牵涉到鸡蛋的摄入。然而，鸡蛋摄入量与此类癌症之间的剂量-反应关系尚不清楚。因此我们进行了剂量-反应荟萃分析，以总结鸡蛋消耗量与患乳腺癌、前列腺癌和妇科癌症风险之间的剂量-反应关系。
2、我们使用美国生物医学信息检索系统（PubMed）和荷兰医学文摘数据库（Embase）来检索截止到2015年4月的文献，以鉴定相关的前瞻性观察研究。我们使用随机效应模型估算总体相对风险度（RR）和95％置信区间（95％CI）。
3、对于乳腺癌，线性剂量反应荟萃分析发现风险没有显著增加（每周多食用5个鸡蛋的RR：1.05，95％CI 0.99，1.11，n 16023例） 。非线性的证据无统计学意义（P非线性＝0.50，n 15415例），但与没有吃鸡蛋相比，每周食用大于等于5个鸡蛋，患乳腺癌的风险显著增加。每周食用5个鸡蛋的RR是1.04（95％CI 1.01，1.07），每周食用9个鸡蛋的RR是1.09（95％CI 1.03，1.15）。
4、对于其他癌症的研究，通过小规模研究的结果表明(P Egger＝0.04)，每周多吃5个鸡蛋，卵巢癌的总体RR为1.09（95％CI 0.96，1.24，n 2636例）；致命性前列腺癌的总体RR是1.47（95％CI 1.01，2.14，n 609例）。没有发现与总前列腺癌风险相关的证据。
5、虽然我们的结论会被潜在的偏差和混淆所影响，但较高的鸡蛋摄入量可能与患乳腺癌风险的略加升高有关，而且不能排除鸡蛋摄入量与患卵巢癌和致命性前列腺癌之间呈正相关。
#常观世音微语录[超话]##常观世音微语录#
Evidence suggests that egg intake may be implicated in the aetiology of sex hormone-related cancers. However, dose–response relationships between egg intake and such cancers are unclear. Thus, we conducted a dose–response meta-analysis to summarise the dose–response relationships between egg consumption and the risk of breast, prostate and gynaecological cancers. A literature search was performed using PubMed and Embase up to April 2015 to identify relevant prospective observational studies. Summary relative risk (RR) and 95% CI were estimated using a random-effects model. For breast cancer, the linear dose–response meta-analysis found a non-significantly increased risk (RR for an increase of 5 eggs consumed/week: 1.05, 95% CI 0.99, 1.11, n 16023 cases). Evidence for non-linearity was not statistically significant (Pnon-linearity =0.50, n 15415 cases) but consuming ≥5 eggs/week was significantly associated with an increased risk of breast cancer compared with no egg consumption, with the summary RR being 1·04 (95% CI 1.01, 1.07) for consuming 5 eggs/week and 1·09 (95% CI 1.03, 1.15) for consuming about 9 eggs/week. For other cancers investigated, the summary RR for an increase of 5 eggs consumed/week was 1·09 (95% CI 0.96, 1.24, n 2636 cases) for ovarian cancer; 1.47 (95% CI 1.01, 2.14, n 609 cases) for fatal prostate cancer, with evidence of small-study effects (PEgger =0.04). No evidence was found for an association with the risk of total prostate cancer. While our conclusion was tempered by the potential for publication bias and confounding, high egg intake may be associated with a modestly elevated risk of breast cancer, and a positive association between egg intake and ovarian and fatal prostate cancers cannot be ruled out.
《英国营养学杂志》(2015)，114，1099-1107
标题：鸡蛋的摄入与乳腺癌、卵巢癌和前列腺癌：一项前瞻性观察研究的剂量反应荟萃分析
作者：N. keum【1，2】 *， D. H. Lee【1，2】, N. Marchand1, H. oh【1，2】, H. Liu【3】, D. aune【4，5】, D. C. Greenwood【6】，E. L. giovannucci1,【2，7】
1、美国波士顿哈佛大学陈曾熙公共卫生学院营养学系
2、美国波士顿哈佛大学陈曾熙公共卫生学院流行病学系
3、中国浙江大学流行病学与卫生统计学系
4、挪威特隆赫姆挪威科技大学医学院公共安全与综合医疗系
5、英国伦敦帝国理工学院流行病学与生物统计学系
6、英国利兹大学生物统计学系
7、美国马萨诸塞州波士顿布列根和妇女医院和哈佛医学院医学部钱宁网络医学系
摘要：
1、有证据表明，与性激素相关的癌症的病因可能牵涉到鸡蛋的摄入。然而，鸡蛋摄入量与此类癌症之间的剂量-反应关系尚不清楚。因此我们进行了剂量-反应荟萃分析，以总结鸡蛋消耗量与患乳腺癌、前列腺癌和妇科癌症风险之间的剂量-反应关系。
2、我们使用美国生物医学信息检索系统（PubMed）和荷兰医学文摘数据库（Embase）来检索截止到2015年4月的文献，以鉴定相关的前瞻性观察研究。我们使用随机效应模型估算总体相对风险度（RR）和95％置信区间（95％CI）。
3、对于乳腺癌，线性剂量反应荟萃分析发现风险没有显著增加（每周多食用5个鸡蛋的RR：1.05，95％CI 0.99，1.11，n 16023例） 。非线性的证据无统计学意义（P非线性＝0.50，n 15415例），但与没有吃鸡蛋相比，每周食用大于等于5个鸡蛋，患乳腺癌的风险显著增加。每周食用5个鸡蛋的RR是1.04（95％CI 1.01，1.07），每周食用9个鸡蛋的RR是1.09（95％CI 1.03，1.15）。
4、对于其他癌症的研究，通过小规模研究的结果表明(P Egger＝0.04)，每周多吃5个鸡蛋，卵巢癌的总体RR为1.09（95％CI 0.96，1.24，n 2636例）；致命性前列腺癌的总体RR是1.47（95％CI 1.01，2.14，n 609例）。没有发现与总前列腺癌风险相关的证据。
5、虽然我们的结论会被潜在的偏差和混淆所影响，但较高的鸡蛋摄入量可能与患乳腺癌风险的略加升高有关，而且不能排除鸡蛋摄入量与患卵巢癌和致命性前列腺癌之间呈正相关。
#常观世音微语录[超话]##常观世音微语录#
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