#痤疮# 您想不到的后遗症
痘坑～众所周知，就是痤疮后留下的萎缩性瘢痕。
但丘疹性痤疮瘢痕临床多见，患者却往往很茫然，比如，这位痤疮患者，就诊时问我：医生，我腮帮子摸着疙疙瘩瘩的，是什么？
查体：双侧下颌部丘疹，白色至淡黄色，米粒至绿豆大小，崩紧皮肤时明显，呈鹅卵石样外观。
诊断：丘疹型痤疮瘢痕
了解一下丘疹型痤疮瘢痕：
病因：痤疮相关，但具体发病机制不确切，可能因为痤疮炎症后毛囊周围的胶原蛋白和弹性纤维的破坏，从而导致丘疹性痤疮疤痕
好发部位：下颌为主，其次是胸部、背部和肩部
临床表现：鹅卵石样丘疹，突出皮面，质地软。多为肤色，或者呈色素减退或色素沉着。好发于鼻部及下颌等部位。
治疗：面部及下颌部位，推荐点阵激光。
躯干部位，根据治疗需求选择局部封闭治疗。
参考文献
1. Layton, A. M., Henderson, C. A., & Cunliffe, W. J. (1994). A clinical evaluation of acne scarring and its incidence. Clinical and experimental dermatology, 19(4), 303-308.
2.Goodman, G. J. (2021). Commentary on A Neglected Acne Scar Type: Papular Acne Scars and Their Correlations With Keloid Scars. Dermatologic Surgery, 47(10), 1352-1353. https://t.cn/A6KxSef3
痘坑～众所周知，就是痤疮后留下的萎缩性瘢痕。
但丘疹性痤疮瘢痕临床多见，患者却往往很茫然，比如，这位痤疮患者，就诊时问我：医生，我腮帮子摸着疙疙瘩瘩的，是什么？
查体：双侧下颌部丘疹，白色至淡黄色，米粒至绿豆大小，崩紧皮肤时明显，呈鹅卵石样外观。
诊断：丘疹型痤疮瘢痕
了解一下丘疹型痤疮瘢痕：
病因：痤疮相关，但具体发病机制不确切，可能因为痤疮炎症后毛囊周围的胶原蛋白和弹性纤维的破坏，从而导致丘疹性痤疮疤痕
好发部位：下颌为主，其次是胸部、背部和肩部
临床表现：鹅卵石样丘疹，突出皮面，质地软。多为肤色，或者呈色素减退或色素沉着。好发于鼻部及下颌等部位。
治疗：面部及下颌部位，推荐点阵激光。
躯干部位，根据治疗需求选择局部封闭治疗。
参考文献
1. Layton, A. M., Henderson, C. A., & Cunliffe, W. J. (1994). A clinical evaluation of acne scarring and its incidence. Clinical and experimental dermatology, 19(4), 303-308.
2.Goodman, G. J. (2021). Commentary on A Neglected Acne Scar Type: Papular Acne Scars and Their Correlations With Keloid Scars. Dermatologic Surgery, 47(10), 1352-1353. https://t.cn/A6KxSef3
The 2024 China Brand Day events are held at the Shanghai World Expo Exhibition and Convention Center today and will last through May 14. By setting up a booth for the first time, Suzhou depicts its city image from the brand themes of cultural tourism, modern life, and unique industrial clusters.https://mp.weixin.qq.com/s/3NsC_hEvqQmrUzmJwYSoIA
NEW ARTICLE: NONI Fruit and CANCER - Morinda citrifolia (Noni) as an Anti-cancer superfood - New Research - 5 papers reviewed
The Noni plant (Morinda citrifolia L.) is a small evergreen tree with over 200 phytochemical compounds identified
grows primarily in coastal tropical regions up to 1330 feet above sea level, and is believed to have originated in Southeast Asia and spread across to Australia, Pacific Basin, and the Caribbean
Its anti-cancer properties have recently drawn the attention of researchers, with over 50 preclinical studies
Apart from “noni”, which is the Hawaiian name, it is also known as “nono” in Tahiti, “kura” in the Fiji Islands, and cheese fruit in Australia
Noni fruits are thick & ovoid. When unripe, they are green and when fully mature, yellowish-white. During the ripening process, the fruits have a tender, watery flesh, and a cheese scent that is pungent
Phytochemicals isolated from noni include: phenolic acids, anthraquinones, flavonoids, iridoids, ketones, lignans, nucleosides, sterols, and fatty acid carotenoids, fatty acid glycosides, betalains, indoles, glucosinolates, organo-sulfides, sulfides, mono or polyphenolic compounds, terpenes (isoprenoids, terpenoids), etc
also quinones and anthraquinones that support health metabolism and have anti-cancer effects
Coumarins like scopoletin, used for treatments against obesity, anti-cancer and metabolic defects
Lignans and neolignans identified in noni effective for anticancer and antidiabetic treatments
triterpenoid compounds found to treat obesity-related metabolic dysfunction
Noni leaves, roots, and seeds also have strong antimicrobial, anticancer, and antioxidant treatment effects due to high content of phytochemicals
majority of in vitro studies displayed pro-apoptotic, antiangiogenesis, antimigratory, antitumor, and antiproliferative effects
breast cancer, colon cancer, liver, skin (in vitro): induce apoptosis, cell cycle arrest, activation of p53, inhibited cell migration
2022 Nov (Kumar et al): “anticancer activities of M. citrifolia is evidently shown in breast and lung cancer models in which the tumor volume is significantly decreased through apoptosis as well as disruption in cell migration and proliferation pathways.”
Also found to enhance chemo while reducing chemo toxicity:
2024 Apr (Ali et al): “combined use of noni with cyclophosphamide potentially enhances the antitumor activity of cyclophosphamide and suppresses myelotoxicity and hepatotoxicity induced by cyclophosphamide in tumor-bearing mice.”
Noni is considered one of the “anti-cancer superfoods” in Asia and Australiasia, along with soursop, apricot seeds, CBD Oil, pomegranate, mangosteen, goji berries, acai berries, etc
新文章： 诺丽果与癌症--海巴戟（诺丽果）是一种抗癌的超级食品--新研究--5篇论文综述
诺丽（Morinda citrifolia L.）是一种常绿小乔木，已发现有200多种植物化学物质。
主要生长在海拔最高达 1330 英尺的热带沿海地区，据说起源于东南亚，后来传播到澳大利亚、太平洋盆地和加勒比海地区。
它的抗癌特性最近引起了研究人员的注意，已有 50 多项临床前研究证实了这一点
除了夏威夷语中的 "诺丽"，它在塔希提岛还被称为 "nono"，在斐济群岛被称为 "kura"，在澳大利亚被称为奶酪果
诺丽果实厚实，呈卵圆形。未成熟时呈绿色，完全成熟后呈黄白色。在成熟过程中，果实肉质细嫩，呈水状，并散发出刺鼻的奶酪香味。
从诺丽果中分离出的植物化学物质包括：酚酸、蒽醌类、黄酮类、虹苷类、酮类、木脂素、核苷类、甾醇类、脂肪酸类胡萝卜素、脂肪酸苷、甜菜苷、吲哚、葡萄糖苷酸盐、有机硫化物、硫化物、单酚或多酚化合物、萜类（异戊烯类、萜类）等。
还有醌类和蒽醌类化合物，它们支持健康的新陈代谢并具有抗癌作用
香豆素（如莨菪亭），用于治疗肥胖症、抗癌和代谢缺陷
在诺丽果中发现的木酚素和新木酚素可用于抗癌和抗糖尿病治疗
发现的三萜类化合物可治疗与肥胖有关的代谢功能障碍
由于含有大量植物化学物质，诺丽叶、根和种子还具有很强的抗菌、抗癌和抗氧化治疗效果
大多数体外研究显示了促进细胞凋亡、抗血管生成、抗移行、抗肿瘤和抗增生的作用
乳腺癌、结肠癌、肝脏、皮肤（体外）：诱导细胞凋亡、细胞周期停滞、激活 p53、抑制细胞迁移
2022 年 11 月（库马尔等人）： "M. citrifolia的抗癌活性在乳腺癌和肺癌模型中得到了明显的体现，在这些模型中，肿瘤体积通过细胞凋亡以及细胞迁移和增殖途径的破坏而显著减少。
还发现它能增强化疗效果，同时降低化疗毒性：
2024 年 4 月（Ali 等人）： "诺丽与环磷酰胺的联合使用可能会增强环磷酰胺的抗肿瘤活性，并抑制环磷酰胺在肿瘤小鼠体内引起的骨髓毒性和肝毒性"。
诺丽与酸浆果、杏籽、CBD 油、石榴、山竹果、枸杞子、巴西莓等一起被认为是亚洲和澳大拉西亚的 "抗癌超级食品"。
The Noni plant (Morinda citrifolia L.) is a small evergreen tree with over 200 phytochemical compounds identified
grows primarily in coastal tropical regions up to 1330 feet above sea level, and is believed to have originated in Southeast Asia and spread across to Australia, Pacific Basin, and the Caribbean
Its anti-cancer properties have recently drawn the attention of researchers, with over 50 preclinical studies
Apart from “noni”, which is the Hawaiian name, it is also known as “nono” in Tahiti, “kura” in the Fiji Islands, and cheese fruit in Australia
Noni fruits are thick & ovoid. When unripe, they are green and when fully mature, yellowish-white. During the ripening process, the fruits have a tender, watery flesh, and a cheese scent that is pungent
Phytochemicals isolated from noni include: phenolic acids, anthraquinones, flavonoids, iridoids, ketones, lignans, nucleosides, sterols, and fatty acid carotenoids, fatty acid glycosides, betalains, indoles, glucosinolates, organo-sulfides, sulfides, mono or polyphenolic compounds, terpenes (isoprenoids, terpenoids), etc
also quinones and anthraquinones that support health metabolism and have anti-cancer effects
Coumarins like scopoletin, used for treatments against obesity, anti-cancer and metabolic defects
Lignans and neolignans identified in noni effective for anticancer and antidiabetic treatments
triterpenoid compounds found to treat obesity-related metabolic dysfunction
Noni leaves, roots, and seeds also have strong antimicrobial, anticancer, and antioxidant treatment effects due to high content of phytochemicals
majority of in vitro studies displayed pro-apoptotic, antiangiogenesis, antimigratory, antitumor, and antiproliferative effects
breast cancer, colon cancer, liver, skin (in vitro): induce apoptosis, cell cycle arrest, activation of p53, inhibited cell migration
2022 Nov (Kumar et al): “anticancer activities of M. citrifolia is evidently shown in breast and lung cancer models in which the tumor volume is significantly decreased through apoptosis as well as disruption in cell migration and proliferation pathways.”
Also found to enhance chemo while reducing chemo toxicity:
2024 Apr (Ali et al): “combined use of noni with cyclophosphamide potentially enhances the antitumor activity of cyclophosphamide and suppresses myelotoxicity and hepatotoxicity induced by cyclophosphamide in tumor-bearing mice.”
Noni is considered one of the “anti-cancer superfoods” in Asia and Australiasia, along with soursop, apricot seeds, CBD Oil, pomegranate, mangosteen, goji berries, acai berries, etc
新文章： 诺丽果与癌症--海巴戟（诺丽果）是一种抗癌的超级食品--新研究--5篇论文综述
诺丽（Morinda citrifolia L.）是一种常绿小乔木，已发现有200多种植物化学物质。
主要生长在海拔最高达 1330 英尺的热带沿海地区，据说起源于东南亚，后来传播到澳大利亚、太平洋盆地和加勒比海地区。
它的抗癌特性最近引起了研究人员的注意，已有 50 多项临床前研究证实了这一点
除了夏威夷语中的 "诺丽"，它在塔希提岛还被称为 "nono"，在斐济群岛被称为 "kura"，在澳大利亚被称为奶酪果
诺丽果实厚实，呈卵圆形。未成熟时呈绿色，完全成熟后呈黄白色。在成熟过程中，果实肉质细嫩，呈水状，并散发出刺鼻的奶酪香味。
从诺丽果中分离出的植物化学物质包括：酚酸、蒽醌类、黄酮类、虹苷类、酮类、木脂素、核苷类、甾醇类、脂肪酸类胡萝卜素、脂肪酸苷、甜菜苷、吲哚、葡萄糖苷酸盐、有机硫化物、硫化物、单酚或多酚化合物、萜类（异戊烯类、萜类）等。
还有醌类和蒽醌类化合物，它们支持健康的新陈代谢并具有抗癌作用
香豆素（如莨菪亭），用于治疗肥胖症、抗癌和代谢缺陷
在诺丽果中发现的木酚素和新木酚素可用于抗癌和抗糖尿病治疗
发现的三萜类化合物可治疗与肥胖有关的代谢功能障碍
由于含有大量植物化学物质，诺丽叶、根和种子还具有很强的抗菌、抗癌和抗氧化治疗效果
大多数体外研究显示了促进细胞凋亡、抗血管生成、抗移行、抗肿瘤和抗增生的作用
乳腺癌、结肠癌、肝脏、皮肤（体外）：诱导细胞凋亡、细胞周期停滞、激活 p53、抑制细胞迁移
2022 年 11 月（库马尔等人）： "M. citrifolia的抗癌活性在乳腺癌和肺癌模型中得到了明显的体现，在这些模型中，肿瘤体积通过细胞凋亡以及细胞迁移和增殖途径的破坏而显著减少。
还发现它能增强化疗效果，同时降低化疗毒性：
2024 年 4 月（Ali 等人）： "诺丽与环磷酰胺的联合使用可能会增强环磷酰胺的抗肿瘤活性，并抑制环磷酰胺在肿瘤小鼠体内引起的骨髓毒性和肝毒性"。
诺丽与酸浆果、杏籽、CBD 油、石榴、山竹果、枸杞子、巴西莓等一起被认为是亚洲和澳大拉西亚的 "抗癌超级食品"。
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