死而不僵的Delta，又冒头打了个酱油。

[星星] 葡萄牙那边刚刚上传的序列，accession：EPI_ISL_18766752，感兴趣的可以自己撸一撸；

[星星] 具体来说子分支AY.124；

[星星] 采样日期是2023年12月底；

[星星] 比元祖版的Delta也就多出来50多个核苷酸突变，洒洒水啦~

[星星] 50多个突变里面有45个都是非同义突变，也就是说很可能是庞大而残酷的选择压选出来的，呵呵~

[星星] 45个突变里面有不少免疫缺陷病例持续感染的特征标志突变，而且30来个突变都位于刺突蛋白，于是情况就很明显了，这个选择压果然又是长期体内养蛊的免疫选择压啦，没新意~

[星星] 其中最值得注意的是，Delta刺突蛋白特征定义突变S:T478K已被回退，S:L452R也进一步变成了Q，同时又成功获得了S:N501Y……也就是说当初锁住Delta RBD的桎梏（T478K+L452R组合）已经没有了，并且还打开了通向一大堆新突变的大门（因为N501Y跟茫茫多的RBD突变都有上位效应）；

[星星] 举个例子，大家最熟悉的上位效应应该就是S:Q498R+S:N501Y组合了，当初在Omicron身上已得到充分验证，大幅提升受体亲合度（图二）~

[星星] RBD结构域的氨基酸突变统统复读一下啊：R346N, A372del, R403S, N440K, G446S, Y449N, R452Q, A475V, K478T（回复）, E484K, F486S, Q498R, N501Y……其中R346N和R403S都位于针对当前免疫地形的关键逃逸位点上，其他的449N、475V、484K、486S什么的大伙儿估计也很眼熟了，主打的就是逃逸……另外R19T（回复）和A372del这两个突变似乎有可能带来糖基化方面的变化；

[星星] 当然了，截止目前只有一条单独的序列，没人知道传不传得开，或者说传不开的可能性其实更大。但是这条序列跟之前大多数持续感染养出来的阴间毒株有一点小区别……这条序列是representative sequencing发现的——用人话来说就是随机抽查，查出来这么个大怪物[摊手]

[星星] INSA（葡萄牙国家卫生研究院）已经在展开调查了，后面有消息的话还会跟进。

以上，抢跑完毕。

（图一来自励志哥Ryan Hisner老师）

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