5 "奥英妥珠单抗/贝博萨(BESPONSA)的作用原理是什么？
Besponsa（奥英妥珠单抗）为一种靶向CD22的免疫毒素，已在美国获批用于复发难治ALL患者。Inotuzumab联合mini-hyper-CVD方案用于一线老年的ALL患者。入组50多例患者，均大于60岁，ORR达到98%，三年OS为54%，较历史对照组超出32%，结果令人振奋。另一个获批药物是CD3-CD19的双抗联合，入组17例患者，用于14岁以上患者的一线治疗。
第一阶段4疗程化疗，第二阶段是Besponsa单独应用4个疗程，目前中位随访时间14个月，1年RFS为77%，1年OS为90%，初期的治疗效果非常好，这两个药物未来都可能进入国内，给患者带来很大的益处。去年ASH会报道CD3-CD123双功能抗体，I期临床试验疗效较好，复发难治的患者ORR为40%左右；
今年ASH报道CD3-CD33双功能抗体I期临床试验，入组35例患者，4例获得了CR，初步看到双功能抗体免疫治疗在AML患者中的疗效。CD33免疫毒素有40%的患者能看到原始细胞的下降，而CD123免疫毒素有30%的患者能看到有效，其中有一例获得CR，3例获得CRi。在初期I期临床剂量爬坡的阶段，在AML免疫治疗上看到临床疗效，随着药物剂量和疗程的优化，应该会取得更好的疗效。
奥英妥珠单抗的作用原理是什么？奥英妥珠单抗主要用于治疗复发或难治性的CD22阳性急性淋巴细胞白血病（ALL）。ALL是一种恶性血液病，主要发生在儿童和老年人，其特点是骨髓中淋巴母细胞异常增殖，导致正常造血功能受损，出现贫血、出血、感染等症状。CD22是一种存在于B淋巴细胞表面的分子，约80%的ALL患者的白血病细胞表达CD22。
奥英妥珠单抗的作用机理是通过与CD22结合，将其上连接的一种毒素（叫做卡尔切霉素）输送到白血病细胞内部，从而阻断DNA合成，诱导凋亡。同时，奥英妥珠单抗还可以激活免疫系统，促进自然杀伤细胞和巨噬细胞吞噬白血病细胞。因此，奥英妥珠单抗可以有效地杀灭白血病细胞，减少复发风险，提高生存率。
奥英妥珠单抗（Obinutuzumab）是一种靶向药，也叫做奥加伊妥珠单抗（Ogivri），贝博萨（Besponsa），Inotuzumab Ozogamicin，它是由美国辉瑞（Pfizer）公司生产的。它是一种人源化的单克隆抗体，可以与白血病细胞表面的CD22分子结合，从而引发细胞死亡。如有需要，"
Besponsa（奥英妥珠单抗）为一种靶向CD22的免疫毒素，已在美国获批用于复发难治ALL患者。Inotuzumab联合mini-hyper-CVD方案用于一线老年的ALL患者。入组50多例患者，均大于60岁，ORR达到98%，三年OS为54%，较历史对照组超出32%，结果令人振奋。另一个获批药物是CD3-CD19的双抗联合，入组17例患者，用于14岁以上患者的一线治疗。
第一阶段4疗程化疗，第二阶段是Besponsa单独应用4个疗程，目前中位随访时间14个月，1年RFS为77%，1年OS为90%，初期的治疗效果非常好，这两个药物未来都可能进入国内，给患者带来很大的益处。去年ASH会报道CD3-CD123双功能抗体，I期临床试验疗效较好，复发难治的患者ORR为40%左右；
今年ASH报道CD3-CD33双功能抗体I期临床试验，入组35例患者，4例获得了CR，初步看到双功能抗体免疫治疗在AML患者中的疗效。CD33免疫毒素有40%的患者能看到原始细胞的下降，而CD123免疫毒素有30%的患者能看到有效，其中有一例获得CR，3例获得CRi。在初期I期临床剂量爬坡的阶段，在AML免疫治疗上看到临床疗效，随着药物剂量和疗程的优化，应该会取得更好的疗效。
奥英妥珠单抗的作用原理是什么？奥英妥珠单抗主要用于治疗复发或难治性的CD22阳性急性淋巴细胞白血病（ALL）。ALL是一种恶性血液病，主要发生在儿童和老年人，其特点是骨髓中淋巴母细胞异常增殖，导致正常造血功能受损，出现贫血、出血、感染等症状。CD22是一种存在于B淋巴细胞表面的分子，约80%的ALL患者的白血病细胞表达CD22。
奥英妥珠单抗的作用机理是通过与CD22结合，将其上连接的一种毒素（叫做卡尔切霉素）输送到白血病细胞内部，从而阻断DNA合成，诱导凋亡。同时，奥英妥珠单抗还可以激活免疫系统，促进自然杀伤细胞和巨噬细胞吞噬白血病细胞。因此，奥英妥珠单抗可以有效地杀灭白血病细胞，减少复发风险，提高生存率。
奥英妥珠单抗（Obinutuzumab）是一种靶向药，也叫做奥加伊妥珠单抗（Ogivri），贝博萨（Besponsa），Inotuzumab Ozogamicin，它是由美国辉瑞（Pfizer）公司生产的。它是一种人源化的单克隆抗体，可以与白血病细胞表面的CD22分子结合，从而引发细胞死亡。如有需要，"
#英语[超话]#[awsl]#英语# [哇]#英语流利说#
If You Forget Me
I want you to know one thing
You know how this is
If I look at the crystal moon
at the red branch
of the slow autumn at my window
If I touch near the fire
the impalpable ash,
or the wrinkled body of the log
Everything carries me to you
As if everything that exists
Aromas , light , medals,
Or little boats that sail toward
those isles of your that wait for me ,
Well now.If little by little
You stop loving me ,
I shall stop loving you
Little by little.
If suddenly you forget me
Do not look for me
For I shall already have forgotten you.
If you think it long and mad
the wind of banners
that passes through my life,
And you decide to leave me
at the shore of the heart where I have roots,
Remember,that on that day,at that hour,
I shall lift my arms
And my roots will set off
to seek another land.
But, if each day, each hour,
You feel that you are destined for me
with implacable sweetness,
If each day a flower climbs
up to your lips to seek me,
Ah my love, ah my own,
in me all that fire is repeated,
In me nothing is extinguished or forgotten
My love feeds on your love, beloved,
And as long as you live
it will be in your arms without leaving mine.
If You Forget Me
I want you to know one thing
You know how this is
If I look at the crystal moon
at the red branch
of the slow autumn at my window
If I touch near the fire
the impalpable ash,
or the wrinkled body of the log
Everything carries me to you
As if everything that exists
Aromas , light , medals,
Or little boats that sail toward
those isles of your that wait for me ,
Well now.If little by little
You stop loving me ,
I shall stop loving you
Little by little.
If suddenly you forget me
Do not look for me
For I shall already have forgotten you.
If you think it long and mad
the wind of banners
that passes through my life,
And you decide to leave me
at the shore of the heart where I have roots,
Remember,that on that day,at that hour,
I shall lift my arms
And my roots will set off
to seek another land.
But, if each day, each hour,
You feel that you are destined for me
with implacable sweetness,
If each day a flower climbs
up to your lips to seek me,
Ah my love, ah my own,
in me all that fire is repeated,
In me nothing is extinguished or forgotten
My love feeds on your love, beloved,
And as long as you live
it will be in your arms without leaving mine.
#英语[超话]#
If You Forget Me
I want you to know one thing
You know how this is
If I look at the crystal moon
at the red branch
of the slow autumn at my window
If I touch near the fire
the impalpable ash,
or the wrinkled body of the log
Everything carries me to you
As if everything that exists
Aromas , light , medals,
Or little boats that sail toward
those isles of your that wait for me ,
Well now.If little by little
You stop loving me ,
I shall stop loving you
Little by little.
If suddenly you forget me
Do not look for me
For I shall already have forgotten you.
If you think it long and mad
the wind of banners
that passes through my life,
And you decide to leave me
at the shore of the heart where I have roots,
Remember,that on that day,at that hour,
I shall lift my arms
And my roots will set off
to seek another land.
But, if each day, each hour,
You feel that you are destined for me
with implacable sweetness,
If each day a flower climbs
up to your lips to seek me,
Ah my love, ah my own,
in me all that fire is repeated,
In me nothing is extinguished or forgotten
My love feeds on your love, beloved,
And as long as you live
it will be in your arms without leaving mine.
If You Forget Me
I want you to know one thing
You know how this is
If I look at the crystal moon
at the red branch
of the slow autumn at my window
If I touch near the fire
the impalpable ash,
or the wrinkled body of the log
Everything carries me to you
As if everything that exists
Aromas , light , medals,
Or little boats that sail toward
those isles of your that wait for me ,
Well now.If little by little
You stop loving me ,
I shall stop loving you
Little by little.
If suddenly you forget me
Do not look for me
For I shall already have forgotten you.
If you think it long and mad
the wind of banners
that passes through my life,
And you decide to leave me
at the shore of the heart where I have roots,
Remember,that on that day,at that hour,
I shall lift my arms
And my roots will set off
to seek another land.
But, if each day, each hour,
You feel that you are destined for me
with implacable sweetness,
If each day a flower climbs
up to your lips to seek me,
Ah my love, ah my own,
in me all that fire is repeated,
In me nothing is extinguished or forgotten
My love feeds on your love, beloved,
And as long as you live
it will be in your arms without leaving mine.
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