@ ptpress. com.cn ! I find a mistake on the water-colours book , the experiment 1) is Cerulean blue +Lemon Yellow , to make a comparison, then the experiment 2) should be Cerulean blue + Cadmium Yellow Deep , as the illustration shows. However, the sentence, it says, the experiment 2) is Green + Cadmium Yellow Deep
全球首个种系靶向抗HIV疫苗“eOD-GT8 60聚体纳米颗粒”的第一个I期临床研究证实能诱导B细胞和T细胞2种强反应！30余年的HIV疫苗研发经验告诉我们，只有特异抗原是不够的，尽管在小鼠模型和早期临床研究管用，但全葬送在III期，必需有疫苗特异T细胞免疫（辅助），该I期重点验证T细胞对抗HIV抗体水平的增强作用；eOD-GT8 60聚体纳米颗粒分3部分：60个拷贝基因工程修饰的外层结构域种系靶向版本8、病毒样纳米颗粒lumazine synthase（LumSyn）和佐剂AS01B；eOD-GT8 60mer疫苗在小鼠模型可诱导抗HIV高亲和力广泛中和抗体（bNAb）VRC01，体外试验显示VRC01对90%的HIV亚型有中和作用——新一代结合HIV膜蛋白gp120的CD4结合位点保守区抗体；I期临床由48个健康志愿者（HIV阴性）参与，随机、双盲和安慰剂对照，由乔治华盛顿大学组织实施；结果发现有大量特异性针对疫苗eOD-GT8 60-mer的2个成分——eOD-GT8和LumSyn的多功能CD4 T细胞，反应率分别为84%和93%；CD4辅助T细胞表位“热点”（“hotspots”）优先靶向LumSyn和eOD-GT8，LumSyn有3个表位，对其中1个表位的反应率85%；最重要的是，外周血疫苗特异CD4 T细胞与扩增eOD-GT8特异记忆B细胞相关，就是大幅提高VRC01水平；但抗HIV机制依然单一，期待II/III期！
Moderna还做了mRNA基础的eOD-GT8 60聚体mRNA-1644，即将进入I期。
#微博国际医药##国际创新药闻#
Moderna还做了mRNA基础的eOD-GT8 60聚体mRNA-1644，即将进入I期。
#微博国际医药##国际创新药闻#
#C919全球首次商业载客飞行#
恭喜，中国一定可以！
China’s first large homegrown passenger jet made its inaugural commercial flight on Sunday, flying from Shanghai to Beijing, Chinese state news agency Xinhua reported.
Flying as China Eastern Airlines flight MU9191, the new narrow-body C919 plane left Shanghai at 10:32 a.m. local time. It was welcomed with a water salute after it landed at the Beijing Capital International Airport at 12:31 p.m.
恭喜，中国一定可以！
China’s first large homegrown passenger jet made its inaugural commercial flight on Sunday, flying from Shanghai to Beijing, Chinese state news agency Xinhua reported.
Flying as China Eastern Airlines flight MU9191, the new narrow-body C919 plane left Shanghai at 10:32 a.m. local time. It was welcomed with a water salute after it landed at the Beijing Capital International Airport at 12:31 p.m.
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