【PCS 2022 年度榮耀時刻】
《最有價值的選手 MVP》
PSG Talon Esports PSG Gori
《ALL-PCS 最佳第一隊》
Top: CFO Rest
JG: CFO Gemini
MID: PSG Gori
BOT: CFO Shunn
SUP: JT Enso
《ALL-PCS 最佳第二隊》
Top: FAK YSKM
JG: JT Kongyue
MID: CFO Mission
BOT: DCG Cryscata
SUP: PSG Kaiwing
《ALL-PCS 最佳第三隊》
Top: DCG Leaky
JG: BYG Husha
MID: DCG Nestea
BOT: FAK MnM
SUP: CFO Koala
《最佳潛力獎》
FAK YSKM
FAK Pretender
JT Enso
《最佳進步獎》
BYG Likai
FAK Pretender
JT Enso
《最佳教練團獎》
Deep Cross Gaming
由克萊門主持的完整頒獎影片就在留言處,
記得要點進連結看看完整的頒獎內容喔 (. ❛ ᴗ ❛.)
#PCS2022##2022PCS#
《最有價值的選手 MVP》
PSG Talon Esports PSG Gori
《ALL-PCS 最佳第一隊》
Top: CFO Rest
JG: CFO Gemini
MID: PSG Gori
BOT: CFO Shunn
SUP: JT Enso
《ALL-PCS 最佳第二隊》
Top: FAK YSKM
JG: JT Kongyue
MID: CFO Mission
BOT: DCG Cryscata
SUP: PSG Kaiwing
《ALL-PCS 最佳第三隊》
Top: DCG Leaky
JG: BYG Husha
MID: DCG Nestea
BOT: FAK MnM
SUP: CFO Koala
《最佳潛力獎》
FAK YSKM
FAK Pretender
JT Enso
《最佳進步獎》
BYG Likai
FAK Pretender
JT Enso
《最佳教練團獎》
Deep Cross Gaming
由克萊門主持的完整頒獎影片就在留言處,
記得要點進連結看看完整的頒獎內容喔 (. ❛ ᴗ ❛.)
#PCS2022##2022PCS#
#编委资讯# #詹启敏#
【北京大学詹启敏院士团队发现肿瘤相关巨噬细胞衍生的CCL22在食管鳞状细胞癌中起重要作用】
肿瘤细胞对激活的致癌基因的依赖被认为是一种治疗靶点,但促肿瘤微环境介导的细胞对特定致癌信号分子的成瘾仍有待进一步确定。
2022年8月12日,北京大学詹启敏院士团队在Cellular & Molecular Immunology (IF=22)在线发表题为“Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)”的研究论文,该研究发现肿瘤相关巨噬细胞(TAM)衍生的CCL22在诱导食管鳞状细胞癌(ESCC)中FAK成瘾中的重要作用。在本研究中发现,肿瘤相关巨噬细胞(TAMs)可以产生大量的C-C基序趋化因子22 (CCL22),其在肿瘤间质中的表达与肿瘤内磷酸化黏附激酶(pFAK Tyr397)水平、肿瘤转移和患者生存降低呈正相关。功能上,CCL22激发的的FAK过活化与癌细胞恶性进展增加相关。CCL22诱导的对FAK的成瘾被证明是通过持续抑制肿瘤进展的FAK特异性抑制实现的。
在机制上,该研究发现二酰甘油激酶α (DGKα)作为连接CCL22受体C-C 基序趋化因子受体4 (CCR4)和FAK的信号转导接头,并促进CCL22诱导的FAK/AKT通路的激活。CCL22/CCR4信号通路激活细胞内Ca2+/磷脂酶C-γ1 (PLC-γ1)轴刺激DGKα在酪氨酸残基(Tyr335)上的磷酸化,并促进DGKα转运到质膜上组装DGKα/FAK信号体,这对调节癌细胞对FAK抑制剂的敏感性至关重要。TAM驱动的肿瘤内FAK成瘾的识别为利用肿瘤促进微环境实现显著的抗癌效果提供了机会。
(来源:iNature公众号 https://t.cn/A6SUui0v)
【北京大学詹启敏院士团队发现肿瘤相关巨噬细胞衍生的CCL22在食管鳞状细胞癌中起重要作用】
肿瘤细胞对激活的致癌基因的依赖被认为是一种治疗靶点,但促肿瘤微环境介导的细胞对特定致癌信号分子的成瘾仍有待进一步确定。
2022年8月12日,北京大学詹启敏院士团队在Cellular & Molecular Immunology (IF=22)在线发表题为“Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)”的研究论文,该研究发现肿瘤相关巨噬细胞(TAM)衍生的CCL22在诱导食管鳞状细胞癌(ESCC)中FAK成瘾中的重要作用。在本研究中发现,肿瘤相关巨噬细胞(TAMs)可以产生大量的C-C基序趋化因子22 (CCL22),其在肿瘤间质中的表达与肿瘤内磷酸化黏附激酶(pFAK Tyr397)水平、肿瘤转移和患者生存降低呈正相关。功能上,CCL22激发的的FAK过活化与癌细胞恶性进展增加相关。CCL22诱导的对FAK的成瘾被证明是通过持续抑制肿瘤进展的FAK特异性抑制实现的。
在机制上,该研究发现二酰甘油激酶α (DGKα)作为连接CCL22受体C-C 基序趋化因子受体4 (CCR4)和FAK的信号转导接头,并促进CCL22诱导的FAK/AKT通路的激活。CCL22/CCR4信号通路激活细胞内Ca2+/磷脂酶C-γ1 (PLC-γ1)轴刺激DGKα在酪氨酸残基(Tyr335)上的磷酸化,并促进DGKα转运到质膜上组装DGKα/FAK信号体,这对调节癌细胞对FAK抑制剂的敏感性至关重要。TAM驱动的肿瘤内FAK成瘾的识别为利用肿瘤促进微环境实现显著的抗癌效果提供了机会。
(来源:iNature公众号 https://t.cn/A6SUui0v)
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