#张江企业# 【国内第5款，君实生物CD20xCD3双抗获批临床】近日（2022年7月12日），据CDE官网最新公告，君实生物注射用JS203的临床试验申请获得批准。JS203为公司自主研发的重组人源化抗CD20和CD3双特异性抗体，主要用于复发难治B细胞非霍奇金淋巴瘤的治疗。JS203由抗CD20段和抗CD3段组成，通过联结并活化T细胞(结合CD3)和淋巴瘤细胞(结合CD20)，可有效促进T细胞杀伤淋巴瘤细胞。https://t.cn/A6apbqoZ
#生物医药科技笔记##代谢药物##糖尿病#
2022年7月8日 Provention Bio由于糖尿病药物teplizumab 上市悬而未决，公司将通过私募筹集6000万美元；
1、Provention Bio是一家成立于美国特拉华州，开发旨在截取和预防免疫介导疾病的新型疗法的生物制药公司
2、teplizumab是该公司开发的用于延缓高危个体1型糖尿病(T1D)的CD3抗体药物；1型糖尿病主要是由于β细胞功能缺陷，而这种缺陷来自自身反应性CD4 + 和CD8 + T淋巴细胞选择性破坏β细胞，最终导致的胰岛素分泌不足；teplizumab可能的机制是通过增加Foxp 3 +、CD8 +、CD25 + T细胞，同时维持CD4 + T细胞，减少胰岛β细胞的自身免疫性破坏。
3、Teplizumab上市之路一波三折，最初由MacroGenics开发，2007年礼来引进这款药物，但在2011年的三期临床失败，双方终止合作。Provention在2018年的时候从MacroGenics获得开发权，2019年获得FDA的突破性疗法，然而2021年7月FDA拒绝了该药物的上市，由于数据不充分。
其他：
2021年华东医药子公司杭州中美华东制药有限公司以1.72亿美元金额引进Provention Bio 在研产品——双特异性抗体 PRV-3279 两个临床适应症，获得大中华区的独家临床开发及商业化权益。
2022年7月8日 Provention Bio由于糖尿病药物teplizumab 上市悬而未决，公司将通过私募筹集6000万美元；
1、Provention Bio是一家成立于美国特拉华州，开发旨在截取和预防免疫介导疾病的新型疗法的生物制药公司
2、teplizumab是该公司开发的用于延缓高危个体1型糖尿病(T1D)的CD3抗体药物；1型糖尿病主要是由于β细胞功能缺陷，而这种缺陷来自自身反应性CD4 + 和CD8 + T淋巴细胞选择性破坏β细胞，最终导致的胰岛素分泌不足；teplizumab可能的机制是通过增加Foxp 3 +、CD8 +、CD25 + T细胞，同时维持CD4 + T细胞，减少胰岛β细胞的自身免疫性破坏。
3、Teplizumab上市之路一波三折，最初由MacroGenics开发，2007年礼来引进这款药物，但在2011年的三期临床失败，双方终止合作。Provention在2018年的时候从MacroGenics获得开发权，2019年获得FDA的突破性疗法，然而2021年7月FDA拒绝了该药物的上市，由于数据不充分。
其他：
2021年华东医药子公司杭州中美华东制药有限公司以1.72亿美元金额引进Provention Bio 在研产品——双特异性抗体 PRV-3279 两个临床适应症，获得大中华区的独家临床开发及商业化权益。
Isaac Stern - Mozart: Violin Concertos, Sinfonia Concertante & Concertone
1995
CD1
Wolfgang Amadeus Mozart
01 Violin Concerto No. 1 in B flat major, K. 207: I. Allegro moderato
02 Violin Concerto No. 1 in B flat major, K. 207: II. Adagio
03 Violin Concerto No. 1 in B flat major, K. 207: III. Presto
Isaac Stern, George Szell, Columbia Symphony Orchestra
04 Violin Concerto No. 2 in D major, K. 211: I. Allegro moderato
05 Violin Concerto No. 2 in D major, K. 211: II. Andante
06 Violin Concerto No. 2 in D major, K. 211: III. Rondeau. Allegro
Isaac Stern, Alexander Schneider, English Chamber Orchestra
07 Violin Concerto No. 3 in G major, K. 216: I. Allegro
08 Violin Concerto No. 3 in G major, K. 216: II. Adagio
09 Violin Concerto No. 3 in G major, K. 216: III. Rondeau. Allegro
Isaac Stern, George Szell, The Cleveland Orchestra
CD2
Wolfgang Amadeus Mozart
01 Violin Concerto No. 4 in D major K. 218: I. Allegro
02 Violin Concerto No. 4 in D major K. 218: II. Adagio
03 Violin Concerto No. 4 in D major K. 218: III. Rondeau. Allegro
Isaac Stern, Alexander Schneider, English Chamber Orchestra
04 Violin Concerto No. 5 in A major, K. 219: I. Allegro aperto
05 Violin Concerto No. 5 in A major, K. 219: II. Adagio
06 Violin Concerto No. 5 in A major, K. 219: III. Rondeau. Tempo di menuetto
Isaac Stern, George Szell, Columbia Symphony Orchestra
07 Adagio for Violin and Orchestra in E major, K. 261
08 Rondo for Violin and Orchestra in C major, K. 373
Isaac Stern, Alexander Schneider, English Chamber Orchestra
CD3
Wolfgang Amadeus Mozart
01 Concertone for 2 Violins in C major, K. 190: I. Allegro spiritoso
02 Concertone for 2 Violins in C major, K. 190: II. Andante grazioso
03 Concertone for 2 Violins in C major, K. 190: III. Tempo di Menuetto. Vivace
Isaac Stern, Neil Black, Pinchas Zukerman, Daniel Barenboim, English Chamber Orchestra
04 Sinfonia Concertante in E falt major, K. 364: I. Allegro maestoso
05 Sinfonia Concertante in E falt major, K. 364: II. Andante
06 Sinfonia Concertante in E falt major, K. 364: III. Presto
Isaac Stern, Pinchas Zukerman, Daniel Barenboim, English Chamber Orchestra
1995
CD1
Wolfgang Amadeus Mozart
01 Violin Concerto No. 1 in B flat major, K. 207: I. Allegro moderato
02 Violin Concerto No. 1 in B flat major, K. 207: II. Adagio
03 Violin Concerto No. 1 in B flat major, K. 207: III. Presto
Isaac Stern, George Szell, Columbia Symphony Orchestra
04 Violin Concerto No. 2 in D major, K. 211: I. Allegro moderato
05 Violin Concerto No. 2 in D major, K. 211: II. Andante
06 Violin Concerto No. 2 in D major, K. 211: III. Rondeau. Allegro
Isaac Stern, Alexander Schneider, English Chamber Orchestra
07 Violin Concerto No. 3 in G major, K. 216: I. Allegro
08 Violin Concerto No. 3 in G major, K. 216: II. Adagio
09 Violin Concerto No. 3 in G major, K. 216: III. Rondeau. Allegro
Isaac Stern, George Szell, The Cleveland Orchestra
CD2
Wolfgang Amadeus Mozart
01 Violin Concerto No. 4 in D major K. 218: I. Allegro
02 Violin Concerto No. 4 in D major K. 218: II. Adagio
03 Violin Concerto No. 4 in D major K. 218: III. Rondeau. Allegro
Isaac Stern, Alexander Schneider, English Chamber Orchestra
04 Violin Concerto No. 5 in A major, K. 219: I. Allegro aperto
05 Violin Concerto No. 5 in A major, K. 219: II. Adagio
06 Violin Concerto No. 5 in A major, K. 219: III. Rondeau. Tempo di menuetto
Isaac Stern, George Szell, Columbia Symphony Orchestra
07 Adagio for Violin and Orchestra in E major, K. 261
08 Rondo for Violin and Orchestra in C major, K. 373
Isaac Stern, Alexander Schneider, English Chamber Orchestra
CD3
Wolfgang Amadeus Mozart
01 Concertone for 2 Violins in C major, K. 190: I. Allegro spiritoso
02 Concertone for 2 Violins in C major, K. 190: II. Andante grazioso
03 Concertone for 2 Violins in C major, K. 190: III. Tempo di Menuetto. Vivace
Isaac Stern, Neil Black, Pinchas Zukerman, Daniel Barenboim, English Chamber Orchestra
04 Sinfonia Concertante in E falt major, K. 364: I. Allegro maestoso
05 Sinfonia Concertante in E falt major, K. 364: II. Andante
06 Sinfonia Concertante in E falt major, K. 364: III. Presto
Isaac Stern, Pinchas Zukerman, Daniel Barenboim, English Chamber Orchestra
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